Dramatic Increase in Incidence of Ulcerative Colitis and Crohn's Disease (1988-2011): A Population-Based Study of French Adolescents.

Objectives: Few data are available to describe the changes in incidence of pediatric-onset inflammatory bowel disease (IBD). The aim of this study was to describe changes in incidence and phenotypic presentation of pediatric-onset IBD in northern France during a 24-year period.

Methods: Pediatric-onset IBD (<17 years) was issued from a population-based IBD study in France between 1988 and 2011.

Botulinum toxin: an endoscopic approach for treating fecal incontinence.

Background And Study Aims: Fecal incontinence is a common, distressing condition with limited therapeutic options. Botulinum toxin A (BTX-A) injections have been proposed as a treatment for patients with fecal incontinence. This study aimed to determine the short-term clinical outcomes of BTX-A injections in patients with fecal incontinence of varying etiology.

Impaired fasting pyloric compliance in gastroparesis and the therapeutic response to pyloric dilatation.

Background: Pyloric pressure and compliance have never been investigated in health nor gastroparesis.

Aim: We hypothesised that pyloric pressure and/or compliance may be altered in gastroparesis.

Methods: Fasting pyloric pressure and compliance were investigated in 21 healthy volunteers (HV), 27 gastroparetic patients (GP) and 5 patients who had undergone oesophagectomy without pyloroplasty as positive controls.

Inflammatory pseudotumor of the cerebellum in a patient with Crohn's disease.

Background: Inflammatory pseudotumors are ubiquitous lesions characterized by a polymorphous inflammatory infiltrate containing plasma cells and lymphocytes. In the central nervous system, this pathological condition is rare and the association with Crohn's disease has never been described.

Case Description: A 31-year-old woman with a history of Crohn's disease was referred to our department for progressive headaches and nausea.

Botulinum A toxin as a treatment for overactive rectum with associated faecal incontinence.

Aim: Rectal hypercontractility can lead to faecal incontinence (FI). Botulinum toxin (BT) has been used successfully for the treatment of bladder overactivity. This study aimed to evaluate the therapeutic value of intrarectal injections of BT in inhibiting colorectal contractions and relieving FI in patients suffering from FI as a result of overactive rectal contractions.