Publications by authors named "J Y Suen"
Background: Falls in hospitals continue to burden patients, staff, and health systems. Prevention approaches are varied, as well as their success at preventing falls. Intervention component analysis (ICA) is useful in indicating important features associated with successful interventions in sets of trial with high heterogeneity.
View Article and Find Full Text PDFBackground: Bypass graft surgery is a key surgical intervention for ischemic heart disease (coronary bypass graft surgery) and critical limb ischemia (peripheral bypass graft surgery). Graft occlusion remains a significant clinical problem for both types. Further research into the pathobiological mechanisms of graft occlusion are needed in order to design targeted therapeutic strategies.
View Article and Find Full Text PDFArticle Synopsis
- - Open-lung ventilation during cardiopulmonary bypass (CPB) may help reduce postoperative lung damage in heart transplant patients, based on a study using sheep models to compare ventilatory strategies during surgery.
- - The study found that the group receiving open-lung ventilation had significantly less lung damage and inflammatory cell infiltration compared to the group that received no ventilation (measured by histological scores).
- - Despite showing benefits in lung protection, no significant differences were observed in overall hemodynamic stability between the two groups, indicating the need for more research to confirm these findings in clinical settings.
Background: In this COVID-19 Critical Care Consortium (CCCC) sub-study, we qualified neurological complications associated with SARS-CoV2 infection.
Methods: The CCCC is an international, multicenter study. Eligible patients were COVID-19 patients admitted to intensive care units (ICU) across 23 centers between 1/7/2020 to 6/23/2022.
Article Synopsis
- Escherichia coli is a leading cause of bloodstream infections and sepsis, but existing animal models fail to replicate the complexities of these conditions, hindering the development of effective treatments.
- Researchers aimed to create a more accurate large-animal model of septic shock using sheep, by infusing a specific strain of antibiotic-resistant E. coli and closely monitoring their health over 48 hours.
- The study successfully induced septic shock in five sheep, showing consistent and reproducible results, including significant drops in blood pressure and increases in lactate levels following the bacterial infusion.