Risk of Reinfection and Incidence of Chronic Symptoms After SARS-CoV-2 Infections.

This study showed that a severe acute respiratory syndrome coronavirus 2 infection reduced the risk of reinfection among vaccinated individuals by 0.50 (95% CI, 0.39-0.

A Novel Anti-nucleocapsid Antibody Avidity Method for Identifying SARS-CoV-2 Reinfections.

Detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfections is challenging with current serology assays and is further complicated by the marked decrease in routine viral testing practices as viral transmission increased during Omicron. Here, we provide proof-of-principle that high-avidity anti-nucleocapsid (N) antibodies detects reinfections after a single infection with higher specificity (85%; 95% confidence interval [95% CI], 80%-90%) compared to anti-N antibody levels (72%; 95% CI, 66%-79%) in a vaccinated cohort. This method could be used to retroactively investigate the epidemiology and incremental long-term health consequences of SARS-CoV-2 reinfections.

Mitochondrial genome of the jack silverside, (Atherinopsidae, Atheriniformes), a nearshore fish of the California Current Ecosystem.

The jack silverside (), also referred to as jacksmelt, is a neotropical silverside fish that inhabits nearshore shallow waters of the California Current Ecosystem in the Northeast Pacific Ocean, ranging from the coast of Oregon, USA, in the north to as far south as Baja California, Mexico. This fish is the sole member of its genus and is a commonly taken species when hook-and-line fishing in pelagic-neritic environments including bays, estuaries, kelp forests, and along sand beaches. Here we report the first complete mitochondrial genome of jack silverside consisting of 16,519 bp nucleotides and encoding 13 protein-coding regions, 12S and 16S rRNAs, 22 tRNAs, and an 841 bp D-loop control region.

Redox sensor NPGPx restrains ZAP70 activity and modulates T cell homeostasis.

Emerging evidences implicate the contribution of ROS to T cell activation and signaling. The tyrosine kinase, ζ-chain-associated protein of 70 kDa (ZAP70), is essential for T cell development and activation. However, it remains elusive whether a direct redox regulation affects ZAP70 activity upon TCR stimulation.