Dual-Locked Enzyme-Activatable Fluorescence Probes for Precise Bioimaging.

Real-time visualization of endogenous enzymes not only helps reveal the underlying biological principles but also provides pathological information for cancer/disease diagnosis and even treatment guidance. To this end, enzyme-activatable fluorescence probes are frequently fabricated that turn their fluorescence signals "on" exclusively at the enzyme-rich region, thus enabling noninvasive and real-time imaging of enzymes of interest at the molecular level with superior sensitivity and selectivity. However, in a complex biological context, commonly used single enzyme-activatable (i.

Ultralight Carbon Tube Foam-Derived SiC Nanofibrous Aerogels with Arbitrary Shape, Excellent Rigidity, and Resilience for Thermal Insulation.

Ceramic aerogels are promising high-temperature thermal insulation materials due to their outstanding thermal stability and oxidation resistance. However, restricted by nanoparticle-assembled network structures, conventional ceramic aerogels commonly suffer from inherent brittleness, volume shrinkage, and structural collapse at high temperatures. Here, to overcome such obstacles, 3D ultralight and highly porous carbon tube foams (CTFs) were designed and synthesized as the carbonaceous precursors, where melamine foams were used as the sacrificial templates to form the hollow and thin-wall network structures in the CTFs (density: ∼4.

AGD1/USP10/METTL13 complexes enhance cancer stem cells proliferation and diminish the therapeutic effect of docetaxel via CD44 m6A modification in castration resistant prostate cancer.

Background: Most patients with prostate cancer inevitably progress to castration-resistant prostate cancer (CRPC), at which stage chemotherapeutics like docetaxel become the first-line treatment. However, chemotherapy resistance typically develops after an initial period of therapeutic efficacy. Increasing evidence indicates that cancer stem cells confer chemotherapy resistance via exosomes.

The Protective Effect of IL-17A in Pneumonic Plague Can Be Compensated by Effective Vaccines and Immunization Strategies in Mice.

Plague, caused by , poses a public health threat not only due to sporadic outbreaks across the globe but also due to its potential as a biothreat agent. Ironically, among the seven deadliest pandemics in global history, three were caused by . Pneumonic plague, the more contagious and severe form of the disease, is difficult to contain, requiring either prophylactic antibiotic treatment or vaccination.