Design, Synthesis, and Antioxidant and Anti-Tyrosinase Activities of ()-5-Benzylidene-2-(naphthalen-1-ylamino)thiazol-4(5)-one Analogs: In Vitro and In Vivo Insights.

Fifteen compounds (-) constructed on a hybrid structure combining a β-phenyl-α,β-unsaturated carbonyl template and a 2-aminothiazol-4(5)-one scaffold were designed and synthesized as potential novel anti-tyrosinase substances. Two compounds ( and ) showed more potent inhibition against mushroom tyrosinase than kojic acid, and the inhibitory activity of (IC value: 1.60 μM) was 11 times stronger than that of kojic acid.

TransRAUNet: A Deep Neural Network with Reverse Attention Module Using HU Windowing Augmentation for Robust Liver Vessel Segmentation in Full Resolution of CT Images.

Liver cancer has a high mortality rate worldwide, and clinicians segment liver vessels in CT images before surgical procedures. However, liver vessels have a complex structure, and the segmentation process is conducted manually, so it is time-consuming and labor-intensive. Consequently, it would be extremely useful to develop a deep learning-based automatic liver vessel segmentation method.

Kinematic and kinetic characteristics of individuals with coping lateral ankle sprain during landing and walking/running tasks: A systematic review with meta-analysis.

Background: We aimed to synthesize the kinematics and kinetics during landing and walking/running tasks of ankle copers compared with patients with chronic ankle instability and controls.

Methods: We systematically searched PubMed, CINAHL, SPORTDiscus, and Web of Science. Tri-planar lower extremity biomechanics (joint angle and moment at maximum and initial contact, and joint displacement) were synthesized using standard mean difference and 95 % confidence intervals.

Integrative Transcriptome-Wide Association Study With Expression Quantitative Trait Loci Colocalization Identifies a Causal VAMP8 Variant for Nasopharyngeal Carcinoma Susceptibility.

Nasopharyngeal carcinoma (NPC) is an Asia-prevalent malignancy, yet its genetic underpinnings remain incompletely understood. Here, a transcriptome-wide association study (TWAS) is conducted on NPC, leveraging gene expression prediction models based on epithelial tissues and genome-wide association study (GWAS) summary statistics from 1577 NPC cases and 6359 controls of southern Chinese descent. The TWAS identifies VAMP8 on chromosome 2p11.

Toward Customizable Smart Gels: A Comprehensive Review of Innovative Printing Techniques and Applications.

New production technologies have transformed modern engineering fields, including electronics, mechanics, robotics, and biomedicine. These advancements have led to the creation of smart materials such as alloys, polymers, and gels that respond to various stimuli. This review focuses on smart materials (SMs), including their variety and fabrication techniques, that can be used to construct three- or four-dimensional structures.