Publications by authors named "J Y Nong"
Red blood cells (RBCs) serve as natural transporters and can be modified to enhance the pharmacokinetics and pharmacodynamics of a protein cargo. Affinity targeting of Factor IX (FIX) to the RBC membrane is a promising approach to improve the (pro)enzyme's pharmacokinetics. For RBC targeting, purified human FIX was conjugated to the anti-mouse glycophorin A monoclonal antibody Ter119.
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- Small cell lung cancer (SCLC) is aggressive, with aneuploid circulating tumor cells (DTCs) and endothelial cells (DTECs) believed to drive metastasis, but their clinical significance is still unclear.
- A study used advanced techniques to analyze DTCs and DTECs from 30 SCLC patients, including genetic sequencing to identify mutations in specific cell subtypes.
- Findings showed higher levels of DTCs and DTECs compared to circulating tumor cells, with certain detections linked to poorer survival outcomes and lower effectiveness of treatment, emphasizing the importance of these cells in patient prognosis.
Background: Neuroblastoma is the most prevalent extracranial solid tumor in pediatric populations worldwide, representing 8-10% of childhood malignancies and contributing to approximately 15% of pediatric cancer-related fatalities. This study aims to report global trends in the incidence, mortality, and disability-adjusted life years (DALYs) of childhood neuroblastoma from 1990 to 2021.
Methods: The study utilized data from the Global Burden of Disease (GBD) database to analyze neuroblastoma incidence, mortality, and DALYs in children aged 0-14 years.