Generation of Pure Highly Functional Human Anti-Tumor Specific Cytotoxic T Lymphocytes With Stem Cell-Like Memory Features for Melanoma Immunotherapy.

Adoptive immunotherapy based on the transfer of anti-tumor cytotoxic T lymphocytes (CTLs) is a promising strategy to cure cancers. However, rapid expansion of numerous highly functional CTLs with long-lived features remains a challenge. Here, we constructed NIH/3T3 mouse fibroblast-based artificial antigen presenting cells (AAPCs) and precisely evaluated their ability to circumvent this difficulty.

Direct Toll-Like Receptor 8 signaling increases the functional avidity of human CD8+ T lymphocytes generated for adoptive T cell therapy strategies.

Adoptive transfer of in vitro activated and expanded antigen-specific cytotoxic T lymphocytes (CTLs) is a promising therapeutic strategy for infectious diseases and cancers. Obtaining in vitro a sufficient amount of highly specific cytotoxic cells and capable of retaining cytotoxic activity in vivo remains problematic. We studied the role of Toll-Like Receptor-8 (TLR8) engagement on peripheral CTLs activated with melanoma antigen MART-1-expressing artificial antigen-presenting cells (AAPCs).

Noise effect on comfort in open-space offices: development of an assessment questionnaire.

It is currently accepted that noise is one of the most important annoyance factors in open-space offices. However, noise levels measured in open spaces of the tertiary sector rarely exceed 65 dB(A). It, therefore, appears necessary to develop a tool that can be used to assess the noise environment of these offices and identify the parameters to be taken into consideration when assessing the noise annoyance.

Implementation of diffraction in a ray-tracing model for the prediction of noise in open-plan offices.

Sound prediction in open-plan offices is a real challenge because of the complexity of the layout of such offices, and therefore because of the multitude of acoustic phenomena involved. One such phenomenon, of primary importance, and not the least challenging of them, is the diffraction by screens and low dividers that usually partition the workspace. This paper describes implementing the equations of the Uniform Theory of Diffraction [McNamara et al.

Survey of noise exposure and background noise in call centers using headphones.

Call centers represent one of the fastest growing industries. However, there are health and safety hazards unique to this new industry. One of these potential hazards is hearing impairment caused by headsets.