Fluorous-Phase- and Chiral-Axis-Enhanced Fluorescent Sensitivity and Chemoselectivity for Cysteine Recognition.

Highly fluorinated naphthyl aldehyde and binaphthyl aldehyde ()- were designed and synthesized for fluorous-phase-based sensing. Greatly enhanced sensitivity and chemoselectivity in going from to ()- in the fluorescent detection of cysteine has been discovered. This is attributed to the increased structural rigidity of the axially chiral binaphthyl unit in ()- upon reaction with cysteine to form the corresponding thiazolidine product.

Indications for continuous electroencephalography and frequency of electrographic seizure detection in a pediatric and neonatal cardiovascular intensive care unit.

Objective: Seizures are a recognized complication of critical cardiovascular illness in infants and children. We assessed the diagnostic yield of continuous video-electroencephalography (cEEG) in a pediatric and neonatal cardiovascular intensive care unit (CVICU) by the symptoms and risk factors prompting cEEG evaluation.

Methods: This retrospective case series included all consecutive cEEGs in patients ≤21 years old performed in one CVICU over 38 months.

High-Performance Solar-Blind Ultraviolet Photodetectors Based on a Ni/β-GaO Vertical Schottky Barrier Diode.

GaO Schottky photodiodes are being actively explored for solar-blind ultraviolet (SBUV) detection, owing to the fast photoresponse and easy fabrication. However, their performance, limited by the Schottky contact, mostly underperforms the expectations. Herein, a Ni/β-GaO vertical Schottky barrier diode (SBD) with an ultrathin anode electrode is demonstrated.

Zoledronic Acid Regulates Osteoclasts via miR-483-5p in the BRONJ.

Objectives: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe complication of bisphosphonate therapy, with unclear mechanisms. This study investigates the regulatory impact of zoledronic acid (ZOL) on osteoclasts and microRNA (miRNA) expression.

Materials And Methods: Raw264.

Advances in biomaterial-based tissue engineering for peripheral nerve injury repair.

Peripheral nerve injury is a common clinical disease. Effective post-injury nerve repair remains a challenge in neurosurgery, and clinical outcomes are often unsatisfactory, resulting in social and economic burden. Particularly, the repair of long-distance nerve defects remains a challenge.