Metabolic profiling of meningioma reveals novel subgroup-specific biologic insights and outcome dependencies.

Background: Our group and others have recently identified four molecular groups of meningioma, with unique underlying biology and outcomes. The relevance of group-specific metabolite profiles (particularly among hypermetabolic tumours), has not been explored.

Methods: We performed untargeted metabolic profiling of meningiomas representing each molecular group and WHO grade.

Development and validation of a molecular classifier of meningiomas.

Background: Meningiomas exhibit considerable clinical and biological heterogeneity. We previously identified four distinct molecular groups (immunogenic, NF2-wildtype, hypermetabolic, proliferative) that address much of this heterogeneity. Despite the utility of these groups, the stochasticity of clustering methods and the use of multi-omics data for discovery limits the potential for classifying prospective cases.

The importance of a vice chair in a department of surgery: A chair's perspective.

From the perspective of chair, there is essential work to do before designating a vice chair, leader, and/or advocate for departmental inclusivity, and that is to work to create a departmental culture that values diversity, embraces different worldviews, and includes a variety of different perspectives. It is important to empower and resource with protected time and budget a vice chair who can be active and intentional day in and day out to create, maintain (and hopefully expand) an inclusive community. Their work should be augmented with a committee inclusive of staff, faculty, and trainees who can provide feedback and creative ideas.