Microenvironment Mechanical Torque from ZnFeO (ZFO) Micromotors Inhibiting Tumor Migration.

Mechanical force attracts booming attention with the potential to tune the tumor cell behavior, especially in cell migration. However, the current approach for introducing mechanical input is difficult to apply in vivo. How the mechanical force affects cell behavior in situ also remains unclear.

Global, regional and national burden of depressive disorders and attributable risk factors, from 1990 to 2021: results from the 2021 Global Burden of Disease study.

Background: Depressive disorders pose a significant global public health challenge, yet evidence on their burden remains insufficient.

Aims: To report the global, regional and national burden of depressive disorders and their attributable risk factors from 1990 to 2021.

Methods: Data from the Global Burden of Disease 2021 were analyzed for 204 countries and territories from 1990 to 2021.

Blended phenotype of TECPR2-associated hereditary sensory-autonomic neuropathy and Temple syndrome.

Uniparental isodisomy (UPiD) can cause mixed phenotypes of imprinting disorders and autosomal-recessive diseases. We present the case of a 3-year-old male with a blended phenotype of TECPR2-related hereditary sensory and autonomic neuropathy (HSAN9) and Temple syndrome (TS14) due to maternal UPiD of chromosome 14, which includes a loss-of-function founder variant in the TECPR2 gene [NM_014844.5: c.

Radiosynthesis and evaluation of novel F labeled PET ligands for imaging monoacylglycerol lipase.

Monoacylglycerol lipase (MAGL) is a 33 kDa cytosolic serine hydrolase that is widely distributed in the central nervous system and peripheral tissues. MAGL hydrolyzes monoacylglycerols into fatty acids and glycerol, playing a crucial role in endocannabinoid degradation. Inhibition of MAGL in the brain elevates levels of 2-arachidonoylglycerol and leads to decreased pro-inflammatory prostaglandin and thromboxane production.

In vivo Predictors of Focal Type In-stent Restenosis: A Clinical, Angiographical and Optical Coherence Tomography Study.

Introduction：Few studies have evaluated different patterns of in-stent restenosis by optical coherence tomography (OCT). This study aims to identify in vivo predictors for focal restenosis in patients with in-stent restenosis (ISR). Methods: The study recruited patients with ISR who underwent OCT examination in the Cardiology Department of the Affiliated Hospital of Zunyi Medical University from October 2018 to December 2022.