A biophysical basis for the spreading behavior and limited diffusion of Xist.

Xist RNA initiates X inactivation as it spreads in cis across the chromosome. Here, we reveal a biophysical basis for its cis-limited diffusion. Xist RNA and HNRNPK together drive a liquid-liquid phase separation (LLPS) that encapsulates the chromosome.

Risk assessment of potentially toxic elements, microplastics, and microorganisms in groundwater around municipal solid waste landfill.

Risk assessment of potential toxic elements (PTEs), microplastics (MPs) and microorganisms in groundwater around landfills is critical. Waste from landfills seeps into groundwater contaminating water quality, threatening groundwater safety, and negatively affecting the ecosystem. This study explored spatial and temporal changes in PTEs, MPs, and microorganisms in the groundwater around a closed landfill.

Clinical and genetic characteristics of patients with Alagille syndrome in China: identification of six novel and mutations.

Background: Alagille syndrome (ALGS) is a rare disease. The variable clinical manifestations make the diagnosis of ALGS difficult. This study aimed to provide a basis for the early diagnosis of ALGS patients whose clinical identification is difficult and to enrich the spectrum of genetic variants implicated in Chinese children with ALGS.

Selective Degradation of TEADs by a PROTAC Molecule Exhibited Robust Anticancer Efficacy In Vitro and In Vivo.

Genetic mutations in components of the Hippo pathway frequently lead to the aberrant activation of TEADs, which is often associated with cancer. Consequently, TEADs have been actively pursued as therapeutic targets for diseases driven by TEAD overactivation. In this study, we report two series of TEAD PROTACs based on CRBN binders and VHL binders.