Clinical significance of HER2 in urothelial carcinoma and analysis of its correlation with glycolytic metabolic characteristics.

Objective: This study aimed to explore the clinical relevance of Human Epidermal Growth Factor Receptor 2 (HER2) in urothelial carcinoma (UC) and its association with glycolytic metabolic markers, insulin resistance, and beta-cell function, shedding light on potential therapies targeting both HER2 pathways and cancer metabolism.

Methods: In this retrospective analysis, 237 UC patients from the Departments of Urology and Pathology at Shandong Provincial Hospital were examined. From 1 January 2023, to 1 October 2024, patients underwent HER2 testing using immunohistochemistry (IHC).

Prenatal Diagnosis of Caroli's Disease by Ultrasound and MRI Imaging.

Objective: To present the imaging features of Caroli's disease (CD) on prenatal ultrasound and magnetic resonance imaging (MRI).

Methods: This was a retrospective case series of prenatally diagnosed CD between 2017 and 2024. Clinical data from these cases were collected and reviewed.

Prevalence of osteoporosis and associated factors among Chinese adults: a systematic review and modelling study.

Background: Osteoporosis is a degenerative disease of bone metabolism. The epidemiology of osteoporosis varies by age, sex, and geography. There is a lack of information on the prevalence of osteoporosis among Chinese adults.

USP35 promotes the growth of ER positive breast cancer by inhibiting ferroptosis via BRD4-SLC7A11 axis.

Anti-estrogen endocrine therapies greatly improve survival of estrogen receptor positive (ER + ) breast cancer. Unfortunately, about 30% of patients do not respond to endocrine therapies initially. We previously showed that deubiquitinase USP35 and ERα act in a positive feedback loop to promote the carcinogenesis of ER+ breast cancer although it is unclear whether USP35 regulates cell death in ER+ breast cancer.

Acidic Engineering on Buried Interface toward Efficient Inorganic CsPbI Perovskite Light-Emitting Diodes.

Inorganic CsPbI perovskite has emerged as a promising emitter for deep-red light-emitting diodes (LEDs) due to its intrinsic thermal stability and suitable bandgap. However, uncontrollable CsPbI crystallization induced by an alkaline zinc oxide (ZnO) substrate in bulk film-based LEDs leads to insufficient external quantum efficiencies (EQEs) at high brightness, leaving obstacles in commercialization progress. Herein, we demonstrate an effective acidic engineering strategy with wide applicability to modify the surface property of ZnO and regulate CsPbI crystallization.