The 3020insC allele of NOD2 predisposes to early-onset breast cancer.

The NOD2 gene has been associated with susceptibility to Crohn's disease, and more recently with carcinoma of the colon as well. NOD2 is involved in the inflammatory response and the activation of the NFkB pathway. The range of cancer types associated with NOD2 has not been well studied.

[Stromal sarcoma in pregnancy--a case report].

In this paper a case of a young pregnant woman with a uterine tumour of 9 cm in size, which was diagnosed as leiomyoma is presented. The patient was delivered at 33 weeks through caesarean section, during which abdominal viscera were found to be normal. Due to the size of the tumour, as well as its localisation--in the uterine wall in the vicinity of the big uterine vessels--an operation to excise it was postponed until after the puerperium period was over.

[Uterine myomas in pregnancy].

In this paper different views regarding the diagnosis and management of uterine myomas during pregnancy, delivery and puerperium are presented. A review was done of the complications which may develop during pregnancy depending on the sizes of the myomas and their localization in relation to the placenta. Indications for operative management of uterine myomas, given by various authors are presented.

[Congenital absence of the vagina--its diagnostic-therapeutic implications--case report].

Issues relating to diagnosis and reconstructive therapy for developmental anomalies of female genital tract are controversial. The teratogenic influence during the 6th week of intrauterine life, the time for the development of structures such as fallopian tube, uterus and cervix from the Müllerian duct may lead to their defective formation. In a 14 year old girl congenital absence of vagina, cervix developed right half of uterus (rudimentary horn?) and a pelvic kidney was diagnosed by laparoscopy and laparotomy.

[Comparison of vaginal misoprostol and oxytocin for labor induction in post-term pregnancy].

Objectives: To compare labour induction intervals between vaginal misoprostol and intravenous oxytocin as well as side effects of induction in post term pregnancies with intact membranes.

Methods: One hundred women were retrospectively selected to two groups treated with vaginal misoprostol 50 micrograms every 12 hours as needed to maximum 150 micrograms and treated with intravenous oxytocin. The primary outcome measure was time from induction to vaginal delivery.