Perfectionistic concerns and psychological distress: The role of spontaneous emotion regulation during college students' experience with failure.

Perfectionistic concerns are associated with various forms of distress, and research has shown that maladaptive emotion regulation mediates this relation. To our knowledge, this mediation process has not been studied in the lab when an individual experiences distress in the moment. This study was designed to determine (a) whether spontaneous emotion regulation mediates the relation between an experimentally induced experience of failure and distress and (b) whether perfectionistic concerns moderate this indirect effect.

Genetic or pharmacological reduction of cholangiocyte senescence improves inflammation and fibrosis in the mouse.

Background & Aims: Cholangiocyte senescence is important in the pathogenesis of primary sclerosing cholangitis (PSC). We found that CDKN2A (p16), a cyclin-dependent kinase inhibitor and mediator of senescence, was increased in cholangiocytes of patients with PSC and from a PSC mouse model (multidrug resistance 2; ). Given that recent data suggest that a reduction of senescent cells is beneficial in different diseases, we hypothesised that inhibition of cholangiocyte senescence would ameliorate disease in mice.

Bosentan preserves endothelial function in mice overexpressing APP.

This study was designed to test the hypothesis that Alzheimer's disease (AD) is associated with endothelial dysfunction and that chronic endothelin-1 antagonism preserves endothelial function in mice overexpressing the AD amyloid precursor protein (APP). Three groups of mice were studied: C57BL/6 (normal control, n = 6), transgenic mice overexpressing APP (Tg2576, n = 5), and Tg2576 mice fed Bosentan (100 mg/(kg day)(-1)), a combined endothelin A and B receptor antagonist, for 4 months (Tg2576+Bosentan, n = 5). Mice were sacrificed at the age of 7 months.