Linking and GenBank to the National Clinical Cohort Collaborative.

Objective: This project demonstrates the feasibility of connecting medical imaging data and features, SARS-CoV-2 genome variants, with clinical data in the National Clinical Cohort Collaborative (N3C) repository to accelerate integrative research on detection, diagnosis, and treatment of COVID-19-related morbidities. The N3C curated a rich collection of aggregated and de-identified electronic health records (EHR) data of over 18 million patients, including 7.5 million COVID-positive patients, seen at hospitals across the United States.

The impact of mental health disorders on outcomes following total ankle arthroplasty: A systematic review.

Background: The purpose of this systematic review was to evaluate the impact of mental health disorders (MHDs) on the clinical and functional outcomes following total ankle arthroplasty (TAA) for the treatment of end-stage ankle arthritis.

Methods: A systematic review of the EMBASE, MEDLINE, and Cochrane Library databases was conducted in April 2024 following PRISMA guidelines. Data collected included patient demographics, clinical outcomes, complications, and failures.

Decoding brain structure to stage Alzheimer's disease pathology in Down syndrome.

Introduction: Alzheimer's disease (AD) in Down syndrome (DS) is associated with changes in brain structure. It is unknown if thickness and volumetric changes can identify AD stages and if they are similar to other genetic forms of AD.

Methods: Magnetic resonance imaging scans were collected for 178 DS adults (106 nonclinical, 45 preclinical, and 27 symptomatic).

Cohort profile: Health and Attainment of Pupils in a Primary Education National Cohort (HAPPEN) - a hybrid total population cohort in Wales, UK.

Purpose: Health and Attainment of Pupils in a Primary Education National (HAPPEN) is a primary school national cohort which brings together education, health and well-being research in line with the Curriculum for Wales framework. Health, education and social care data are linked and held in the Secure Anonymised Information Linkage (SAIL) Databank. In addition, school-aged children complete the HAPPEN Survey to inform the design and implementation of the Health and Well-being curriculum.