Publications by authors named "J Wolinski"
With the current state of knowledge regarding disorders of facial bone development, including anodontia, the development of a suitable animal model for preclinical studies is essential. The agenesis of dental buds occurs in about 25% of the human population. Prospects for treatment include the use of growth factors, stem cells, and bioengineering.
View Article and Find Full Text PDFProtein maldigestion and malabsorption lead to malnutrition and are a feature of exocrine pancreatic insufficiency (EPI). Although it is the current standard, measurement of nitrogen in stool to assess protease activity is indirect. Up to 80% of hydrolysed proteins appear in blood in the form of peptides, so we developed a method to measure peptide-derived amino acids in plasma as a relevant measure of proteolysis, verified its accuracy, precision, and linearity, and validated it in a porcine model.
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- Preterm infants are highly susceptible to iron deficiency, but understanding of their iron regulation is limited.
- The research aimed to create a suitable animal model by inducing prematurity in piglets, allowing assessment of iron status similar to that of preterm human infants.
- Findings showed that preterm piglets had lower body weight and plasma iron but higher tissue iron and levels of iron-regulatory hormones, indicating a unique pattern of iron metabolism that suggests functional iron deficiency and accumulation.
Background: The possible existence of an acini-islet-acinar (AIA) reflex, involving mutual amylase and insulin interactions, was investigated in the current acute experiment on pigs.
Aim: To confirm the existence of an AIA reflex and justify the placement of the exocrine and endocrine pancreatic components within the same organ.
Methods: The study was performed on six pigs under general anesthesia.
The purpose of this review was to analyze the scientific literature on exocrine pancreatic insufficiency (EPI) in dogs and cats and our own research on porcine model to compare animal- and microbial-derived enzymes in the treatment of animals with this disease. Clinical signs of EPI occur when more than 85% of the pancreatic parenchyma is non-functional. EPI can be a consequence of various diseases.
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