Publications by authors named "J Wist"
Understanding the distribution and variation in inflammatory markers is crucial for advancing our knowledge of inflammatory processes and evaluating their clinical utility in diagnosing and monitoring acute and chronic disease. 1H NMR spectroscopy of blood plasma and serum was applied to measure a composite panel of inflammatory markers based on acute phase glycoprotein signals (GlycA and GlycB) and sub-regions of the lipoprotein derived Supramolecular Phospholipid Composite signals (SPC1, SPC2 and SPC3) to establish normal ranges in two healthy, predominantly white cohorts from Australia (n = 398) and Spain (n = 80; ages 20-70 years). GlycA, GlycB, SPC1 and SPC3 were not significantly impacted by age or sex, but SPC2 (an HDL-related biomarker) was significantly higher in women across all age ranges by an average of 33.
View Article and Find Full Text PDFArticle Synopsis
- Metabolic phenotyping using molecular fingerprints shows promise for clinical diagnostics but faces challenges with data usability and workflow efficiency.* -
- MetaboScope is a comprehensive tool designed for analyzing H nuclear magnetic resonance data, featuring advanced statistical methods for data preprocessing and modeling.* -
- The MetaboScope system operates as a web app in JavaScript, allowing users to process data locally without uploads, and includes resources like tutorials and datasets for easy access and implementation.*
Whilst wound repair in severe burns has received substantial research attention, non-severe burns (<20 % total body surface area) remain relatively understudied, despite causing considerable physiological impact and constituting most of the hospital admissions for burns. Early prediction of healing outcomes would decrease financial and patient burden, and aid in preventing long-term complications from poor wound healing. Lipids have been implicated in inflammation and tissue repair and may play essential roles in burn wound healing.
View Article and Find Full Text PDFArticle Synopsis
- The human ileum has a lot of L-cells that produce hormones like GLP-1 and PYY, which help suppress appetite when we eat.
- A study explored how different diets (high-fiber vs. low-fiber) affect the release of these hormones and their connection to food structure and ileal metabolites.
- Results showed that high-fiber diets significantly boosted PYY release compared to low-fiber, and the study found changes in the ileum's molecular environment after eating, linking it to appetite regulation.
Understanding the intricate ecological interactions within the gut microbiome and unravelling its impact on human health is a challenging task. Bioreactors are valuable tools that have contributed to our understanding of gut microbial ecology. However, there is a lack of studies describing and comparing the microbial diversity cultivated in these models.
View Article and Find Full Text PDF