Publications by authors named "J Wirth"
In both molecular epidemiology and microbial ecology, it is useful to be able to categorize specific strains of microorganisms in either an ingroup or an outgroup in a given population, e.g. to distinguish a pathogenic strain of interest from its non-virulent relatives.
View Article and Find Full Text PDFAround 55 million people worldwide live with dementia, and more are expected due to population ageing. We aimed to investigate associations between healthy diet and mild cognitive impairment and dementia in 1753 older adults aged 60-64 from the PATH (Personality and Total Health Through Life Cohort) study. Healthy diet was defined by the Mediterranean-DASH diet Intervention for Neurological Delay (MIND) and two dietary guideline quality scores (Dietary Guideline Index (DGI) and Index Diet Quality (IDQ)), which were calculated from baseline FFQ.
View Article and Find Full Text PDFInterventions designed to address COVID-19 needed to be rapidly scaled up to the population level, and to address health equity by reaching historically marginalized populations most affected by the pandemic (e.g., racial/ethnic minorities and rural and low socioeconomic status populations).
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- The study investigates different workflows for improving the analysis of chemical diversity in plant root exudates by comparing methods for extraction, chromatography, and data preprocessing.! -
- Two extraction methods were used: one with water and another with methanol, with the latter yielding better results in terms of compound detection, identifying 43 compounds with a dual column method compared to 34 with a single column.! -
- The removal of nutrient solutions before sampling increases signal strength, and open-source software can perform as well as or better than proprietary options in identifying compounds, particularly small polar metabolites.!
Dynein is the primary molecular motor responsible for retrograde intracellular transport of a variety of cargoes, performing successive nanometer-sized steps within milliseconds. Due to the limited spatiotemporal precision of established methods for molecular tracking, current knowledge of dynein stepping is essentially limited to slowed-down measurements in vitro. Here, we use MINFLUX fluorophore localization to directly track CRISPR/Cas9-tagged endogenous dynein with nanometer/millisecond precision in living primary neurons.
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