Publications by authors named "J Winberg"
Article Synopsis
- The study focused on the rising trend of early onset colorectal cancer (EO-CRC) in patients diagnosed between 1999 and 2021, analyzing risk factors compared to late onset colorectal cancer (LO-CRC).
- Out of 61,679 colorectal cancer patients surveyed, 5,561 were classified as EO-CRC, revealing a significant increase in EO-CRC cases over the past decades and identifying key risk factors such as gender, family history, ethnicity, and smoking status.
- EO-CRC patients showed lower rates of common comorbidities and had a significantly lower all-cause mortality rate compared to their LO-CRC counterparts, highlighting the need for targeted screening in high-risk groups, including young people with family histories
Validation and application of an automated multitarget LC-MS/MS method for drugs of abuse testing using exhaled breath as specimen.
J Chromatogr B Analyt Technol Biomed Life Sci
June 2024
Aerosol microparticles in exhaled breath carry non-volatile compounds from the deeper parts of the lung. When captured and analyzed, these aerosol microparticles constitute a non-invasive and readily available specimen for drugs of abuse testing. The present study aimed to evaluate a simple breath collection device in a clinical setting.
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- Tularemia, caused by the bacterium Francisella tularensis, is a rare but serious condition during pregnancy that can lead to various complications for mothers and their babies.
- A systematic review analyzed 52 cases of pregnant patients with tularemia, revealing that oropharyngeal and ulceroglandular forms were the most common, with many cases reported in the second trimester.
- Results suggest that while complications and pregnancy losses occurred, those who received effective antimicrobial treatment experienced fewer adverse outcomes, emphasizing the need for timely recognition and treatment of tularemia during pregnancy.
Article Synopsis
- Francisella tularensis is a highly infectious bacterium that causes tularemia and poses a potential bioterrorism risk, with just 10 organisms needed to cause disease.
- A systematic review of 8878 publications found 410 articles detailing 870 cases treated with various antibiotics, mostly from the U.S., Turkey, and Spain, primarily presenting as ulceroglandular and pneumonic forms.
- The study concluded that aminoglycosides, fluoroquinolones, and tetracyclines are generally effective, with ciprofloxacin showing particularly good outcomes for patients with pneumonic disease, resulting in no fatalities and fewer complications.
Bladder exstrophy is a rare congenital malformation leaving the urinary bladder open in the midline of the abdomen at birth. There is a clear genetic background with chromosome aberrations, but so far, no consistent findings apart from 22q11-duplications detected in about 2%-3% of all patients. Some genes are implicated like the LZTR1, ISL1, CELSR3, and the WNT3 genes, but most are not explained molecularly.
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