Publications by authors named "J Willem Vrijbloed"
Article Synopsis
- Sarcopenia is a major factor causing reduced motor skills in older adults, and current treatments focusing on increasing muscle mass through myostatin inhibitors only offer limited improvement.
- We propose a new treatment, ActR-Fc-nLG3, which combines myostatin inhibition with neuro-muscular stability enhancement, showing improved motor endurance and muscle strength in aged mice compared to traditional myostatin inhibitors.
- Histological findings indicate that ActR-Fc-nLG3 promotes better neuromuscular stability and maintains fiber innervation, potentially preventing muscle atrophy and enhancing neurotransmission efficiency, making it a promising option for treating sarcopenia and similar muscle disorders.
Article Synopsis
- Current strategies to enhance muscle performance focus on inhibiting the myostatin pathway, but previous clinical efforts have not succeeded.
- A new protein, ActR-Fc-nLG3, combines a strong myostatin inhibitor with a domain that supports neuromuscular junctions, leading to improved endurance in young male mice as compared to other treatments.
- The study suggests that the synergistic effect of combining both domains in one molecule, rather than administering them separately, is crucial for this enhanced endurance, highlighting the importance of nerve-muscle interactions in sustaining muscle activity.
Treatment of neuromuscular diseases is still an unsolved problem. Evidence over the last years strongly indicates the involvement of malformation and dysfunction of neuromuscular junctions in the development of such medical conditions. Stabilization of NMJs thus seems to be a promising approach to attenuate the disease progression of muscle wasting diseases.
View Article and Find Full Text PDFSarcopenia, the age-related skeletal muscle decline, is associated with relevant clinical and socioeconomic negative outcomes in older persons. The study of this phenomenon and the development of preventive/therapeutic strategies represent public health priorities. The present document reports the results of a recent meeting of the International Working Group on Sarcopenia (a task force consisting of geriatricians and scientists from academia and industry) held on June 7-8, 2011 in Toulouse (France).
View Article and Find Full Text PDFIntroduction: Sarcopenia is considered to be an enormous burden for both the individuals affected and for society at large. A multifactorial aetiology of this geriatric syndrome has been discussed. Amongst other pathomechanisms, the degeneration of the neuromuscular junction (NMJ) may be of major relevance.
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