Factors influencing period of time between negative second-look laparotomy and ovarian carcinoma recurrence. Multicenter study in Poland.

Objective: The aim of our study was to evaluate factors such as primary clinical stage, presence of ascites, serum CA 125 antigen level, histological type of ovarian cancer, cell differentiation and number of chemotherapy cycles influencing the time of recurrence after negative second-look operations.

Material And Methods: Having observed complete clinical remission in 356 patients with ovarian cancer, second-look laparotomy was performed. In 180 patients complete pathologic remission was detected and in 73 recurrence was observed.

[The value of CA 125 levels in serum, peritoneal fluid and tumor in women with ovarian cancer].

The patients group consisted of 133 women with primary ovarian carcinoma at the average age of 56. According to the size of tumor diagnosed preoperatively, patients were divided into 3 groups: with tumor smaller than 5 cm, with tumor between 5 and 10 cm and over 10 cm. 74 women were tested for antigen CA 125 in the serum preoperatively and all of them were tested for it postoperatively.