Publications by authors named "J Whatley"
Intestinal ultrasound at diagnosis of pediatric inflammatory bowel disease compared to endoscopy.
J Pediatr Gastroenterol Nutr
December 2024
Objectives: Intestinal ultrasound (IU) has emerged as an alternative to detect bowel wall inflammation. The aim of this study was to compare IU findings to clinical disease, fecal calprotectin (FC), and endoscopic findings in newly diagnosed pediatric inflammatory bowel disease (IBD) patients.
Methods: This study was a 1-year, single-center, prospective study.
Introduction: Vaccination against SARS-CoV-2 is an integral pillar of the public health approach to COVID-19. With the emergence of variants of concern that increase transmissibility and escape from vaccine- or infection-induced protection, vaccines have been developed to more closely match the newly circulating SARS-CoV-2 strains to improve protection. The safety and immunogenicity of multiple authorized messenger RNA (mRNA)-based COVID-19 vaccines targeting the omicron sublineage (BA.
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- Monovalent and bivalent COVID-19 vaccines containing the Omicron XBB.1.5 variant were approved for use during the 2023-2024 immunization season and are currently undergoing evaluation in a phase 2/3 study.
- Among participants who previously received previous vaccine doses, those who received the monovalent vaccine showed greater increases in neutralizing antibodies against various SARS-CoV-2 variants compared to those who received the bivalent vaccine.
- The results indicate that the XBB.1.5 mRNA vaccines generate strong immune responses against newer variants, validating the update of COVID-19 vaccines to include the XBB.1.5 spike protein.
Article Synopsis
- A phase 2/3 trial compared the safety and effectiveness of the new bivalent mRNA-1273.222 vaccine, targeting Omicron BA.4/BA.5 variants, against the original mRNA-1273 vaccine used as boosters in adults who had previously received it.
- Results showed that the bivalent vaccine produced stronger neutralizing antibody responses against the Omicron variants while maintaining similar effectiveness against the original virus compared to mRNA-1273.
- The safety profile for mRNA-1273.222 was consistent with the previous vaccine, with no new safety issues found, but further monitoring of vaccine effectiveness and potential new variants is advised.
Outflow tract (OFT) develops from cardiac progenitor cells in the second heart field (SHF) domain. APJ, a G-Protein Coupled Receptor, is expressed by cardiac progenitors in the SHF. By lineage tracing APJ+SHF cells, we show that these cardiac progenitors contribute to the cells of OFT, which eventually give rise to aorta and pulmonary trunk/artery upon its morphogenesis.
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