Publications by authors named "J Wemeau"
Article Synopsis
- APECED syndrome is a rare genetic disorder caused by mutations in the AIRE gene, typically characterized by a triad of symptoms including hypoparathyroidism, adrenal failure, and chronic mucocutaneous candidiasis (CMC), along with other non-endocrine issues.
- In a national study involving 25 patients from 23 families, researchers identified 11 different variants of the AIRE gene, including two previously unreported variants, and found that a majority of patients displayed multiple clinical manifestations.
- The study revealed significant immunological disturbances, such as NK cell lymphopenia and altered B lymphocyte homeostasis, and highlighted a variety of non-endocrine symptoms that could potentially be life-threatening, emphasizing the need for
EXPLORATION AND MANAGEMENT OF THYROID NODULES. Most thyroid nodules are benign (95%) and can benefit from clinical and ultrasound monitoring. Cancers (approximately 5% of nodules) could be suspected, particularly in subjects whose neck was irradiated, in cases of a hard, irregular, evolving nodule, or with very high serum calcitonin (> 100 pg/ml).
View Article and Find Full Text PDFBackground: The aim of this study was to evaluate the role of dual isotope Iodine/Tc-MIBI thyroid scintigraphy (IMS) in discriminating between malignant and benign lesions in indeterminate nodules using quantitative analysis methods.
Methods: Thirty-five consecutive patients with thyroid nodules of indeterminate or non-diagnostic cytology and cold on Iodine scintigraphy (10 Bethesda I, 24 Bethesda III-IV, 1 in which cytology was impossible) underwent IMS between 2017 and 2019 with uptake quantification at two time points ahead of thyroidectomy: early and late. Images were analyzed by two blinded physicians.
Article Synopsis
- - The study evaluated the safety of a reformulated levothyroxine sodium in France, prompted by a request for stricter potency specifications, after an increase in reported adverse events despite previous bioequivalence and purity assurance.
- - Data from safety reports were collected for both old and new formulations, showing a stark increase in total reports for the new formulation, but with most adverse events being non-serious and rates generally comparable between the two formulations.
- - The analysis concluded that the new formulation has a safety profile similar to the old one, indicating that the overall benefits of the new treatment still outweigh the risks associated with its use.