Seleno-auranofin (Et3PAuSe-tagl): synthesis, spectroscopic (EXAFS, 197Au Mössbauer, 31P, 1H, 13C, and 77Se NMR, ESI-MS) characterization, biological activity, and rapid serum albumin-induced triethylphosphine oxide generation.

Seleno-auranofin (SeAF), an analogue of auranofin (AF), the orally active antiarthritic gold drug in clinical use, was synthesized and has been characterized by an array of physical techniques and biological assays. The Mössbauer and extended X-ray absorption fine structure (EXAFS) parameters of the solid compound demonstrate a linear P-Au-Se coordination environment at a gold(I) center, analogous to the structure of auranofin. The (31)P, (13)C, and (1)H NMR spectra of SeAF in chloroform solution closely resemble those of auranofin.

[Acute pancreatitis as a complication of diagnostic gastroduodenal endoscopy at 10 years old girl--case report].

A 10-years old girl with chronic pancreatitis, in whom the symptoms of acute pancreatitis appeared after gastroduodenal endoscopy is described. One hour after endoscopy the following symptoms appeared: unigastric and epigastric pain, intense vomiting, elevated amylase activity in the serum (2744 micro/l) and in urine (23738 micro/l) as well as serum lipase activity (4350 micro/l). Ultrasound of the abdomen revealed the enlargement of the pancreas with hypodense structure in comparison to the examination conducted couple hours earlier, and trace of fluid around the pancreas.

[Precocious puberty caused by McCune-Albright syndrome in a girl aged 6 years and 9 months].

The McCune-Albright syndrome is characterised by polyostotic fibrous dysplasia, "cafe-au-lait" spots and autonomous hyperfunction of various endocrine organs. The authors present the case of a girl at the age of 6 years 9 months with precocious puberty (thelarche III, menarche). High estradiol level (204 pg/ml) and low gonadoptopins concentration as well as their level after GnRH administration suggested ovarian autonomy.

[Evaluation of an atypical clinical presentation for pneumonia caused by Mycoplasma pneumoniae and Chlamydia sp in children].

Mycoplasma pneumoniae and Chlamydia sp. frequently cause atypical pneumonia in children. The study aim was the analysis of clinical picture of pneumonia caused by Mycoplasma pneumoniae and Chlamydia sp.

[Polycystic renal disease in infants].

In the light of the observation of 4 infants with polycystic renal disease the clinical manifestation, diagnosis (with stress laid on USG) and therapeutic management are discussed. Attention is called to the possibility of adult-type polycystic renal disease in neonatal period and infancy. This type of nephropathy is supposed by the authors to be in 2 living children.