Making time for person-centred care.

The ambulance crew tell me you have been admitted to the emergency department with a suspected femoral shaft fracture. I see a scared, frail older person, but I see a sparkle in your eyes that tells me how you made it to 101 years old.

Single ocular injection of a sustained-release anti-VEGF delivers 6months pharmacokinetics and efficacy in a primate laser CNV model.

A potent anti-vascular endothelial growth factor (VEGF) biologic and a compatible delivery system were co-evaluated for protection against wet age-related macular degeneration (AMD) over a 6month period following a single intravitreal (IVT) injection. The anti-VEGF molecule is dimeric, containing two different anti-VEGF domain antibodies (dAb) attached to a human IgG1 Fc region: a dual dAb. The delivery system is based on microparticles of PolyActive™ hydrogel co-polymer.

Comparison of intravenous morphine and paracetamol.

One of the main complaints from patients who present to emergency departments with illness or injury is pain, yet often this is not well managed in emergency settings. Nurse prescribers are in an ideal position to make a rapid assessment and then prescribe and treat patients' pain, and must quickly decide which is the safest and most effective drug for each individual. This article compares intravenous morphine with intravenous paracetamol for managing pain in patients with isolated limb trauma who then require manipulation under sedation.

Three-dimensional phase imaging with a scanning optical-fiber interferometer.

We describe a quantitative method for measuring the phase of a propagating wave field in three dimensions by use of a scanning optical-fiber interferometer. Because phase modulation in the reference arm is exploited, this technique is insensitive to large variations in the intensity of the field being studied and is therefore highly suitable for measurement of phase within spatially confined optical beams. It uses only a single detector and is not reliant on lock-in electronics.