Publications by authors named "J W van Velde"
Article Synopsis
- Hypoxic tumors resist radiation due to low oxygen levels, which reduces the effectiveness of therapy; increasing oxygenation during treatment could enhance radiosensitivity.
- Historical approaches to boost oxygen delivery to tumors have had limited success, but inhibiting cancer cell respiration may yield better results.
- Research shows that the mitochondria-targeted antioxidant MitoQ can effectively radiosensitize breast tumors in mice, suggesting potential for its use alongside radiotherapy in clinical settings.
Article Synopsis
- - The study investigates the long-term effects of bilateral testicular regression (BTR) in individuals, focusing on growth and development outcomes, particularly highlighting suboptimal penile growth often related to genetic factors.
- - BTR, a rare condition with potential vascular and genetic origins, was analyzed in a cross-sectional study involving 35 participants recruited from eight pediatric endocrinology departments in Belgium over three years.
- - Key findings revealed common maternal complications during pregnancy and identified specific genetic variants in some participants, while a centralized review of gonadal tissue contributed to understanding the condition's clinical implications.
The association of overweight, obesity, and long-term obesity with SARS-CoV-2 infection: a meta-analysis of 9 population-based cohorts from the Netherlands Cohorts Consortium.
Bette Loef Jolanda M A Boer Marian Beekman Sophie L Campman Emiel O Hoogendijk Jeroen H P M van der Velde
Int J Obes (Lond)
October 2024
Background: Obesity may affect an individual's immune response and subsequent risk of infection, such as a SARS-CoV-2 infection. It is less clear whether overweight and long-term obesity also constitute risk factors. We investigated the association between the degree and duration of overweight and obesity and SARS-CoV-2 infection.
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- Hypercoagulability is linked to higher levels of coagulation factors and increased thrombin generation, which could be related to type 2 diabetes and other complications like glucose metabolism issues and endothelial dysfunction.
- The study analyzed data from 5,718 participants, tracking diabetes diagnoses over 6.7 years, and found that higher levels of specific coagulation factors correlated with increased risk of developing type 2 diabetes.
- Although glycoprotein acetylation (GlycA) was examined as a potential mediator in these associations, it only explained a small portion of the relationship, suggesting that hypercoagulability plays a significant role in the development of type 2 diabetes.
Article Synopsis
- RXFP2 disruption has been linked to male infertility, specifically through biallelic variants causing spermatogenic arrest at the spermatid stage.
- Past studies have shown RXFP2 is crucial for testicular descent and may also influence postnatal spermatogenesis, although its exact role has been unclear.
- In a family with male infertility and a history of cryptorchidism, genetic analysis revealed significant RXFP2 mutations, which correlated with impaired fertility and demonstrated a loss-of-function in cAMP signaling related to INSL3.