Addition of macrolide antibiotics for hospital treatment of community-acquired pneumonia.

Background: Current guidelines recommend combining a macrolide with a β-lactam antibiotic for the empirical treatment of moderate-to-high severity community-acquired pneumonia (CAP); however macrolide use is associated with potential adverse events and antimicrobial resistance.

Methods: We analysed electronic health data from 8,872 adults in Oxfordshire, UK, hospitalised with CAP between 01-January-2016 and 19-March-2024, who received either amoxicillin or co-amoxiclav as initial treatment. We examined the effects of adjunctive macrolides on 30-day all-cause mortality, time to hospital discharge, and changes in Sequential Organ Failure Assessment (SOFA) score, using inverse probability treatment weighting to address confounding by baseline severity.

Geometric configuration for maximizing photocurrent collection in bulk photovoltaic effect devices.

The bulk photovoltaic effect (BPVE) and its artificial variant generate photocurrent under zero external bias in non-centrosymmetric systems, particularly in on-chip miniaturized metasurface-based photodetectors. Despite significant advancements, enhancing the efficiency of local photocurrent collection remains a challenge, often impeded by non-uniform flow fields in graphene caused by nanoantenna contacts, which lead to carrier transport losses. In this study, we conducted a comprehensive investigation into the regulation of local photocurrent collection in zero-bias optoelectronic metasurface-based photodetectors and explored the impact of nanoantenna array configurations on photocurrent efficiency.

flagellin exacerbates colorectal cancer through activating LRRC19/TRAF6/TAK1 pathway.

The initiation and progression of colorectal cancer (CRC) are intimately associated with genetic, environmental and biological factors. (DSV), a sulfate-reducing bacterium, has been found excessive growth in CRC patients, suggesting a potential role in carcinogenesis. However, the precise mechanisms underlying this association remain incompletely understood.

Atomically Precise Cu Nanoclusters with Thermally Activated Delayed Fluorescence Properties.

Ligand-stabilized metal nanoclusters with atomic precision are considered to be promising materials in the field of light-emitting and harvesting. Among these, nanoclusters with thermally activated delayed fluorescence (TADF) properties are highly sought after. While several gold and silver nanoclusters with TADF properties have been reported in recent years, research on copper counterparts has significantly lagged behind.