Urine Complement Factor Ba Identifies Persistent Acute Kidney Injury and Organ Failures in Critically Ill Adults.

Introduction: Critically ill adults with acute kidney injury (AKI) have high morbidity and mortality and lack treatment options. We assessed the association between complement activation (urine Ba fragment levels), and AKI and organ failures.

Methods: A biorepository of critically ill adults was leveraged.

Incidental Finding of a Low-Grade Appendiceal Mucinous Neoplasm: A Case Study.

Low-grade appendiceal mucinous neoplasms (LAMNs) are rare benign tumors of the appendix with possible life-threatening complications. A 25-year-old female patient presented to the emergency room with abdominal pain with symptoms concerning for acute appendicitis. After imaging, it was decided to proceed with an appendectomy.

A Newly Identified Protective Role of C5a Receptor 1 in Kidney Tubules against Toxin-Induced Acute Kidney Injury.

Acute kidney injury (AKI) remains a major reason for hospitalization with limited therapeutic options. Although complement activation is implicated in AKI, the role of C5a receptor 1 (C5aR1) in kidney tubular cells is unclear. Herein, aristolochic acid nephropathy (AAN) and folic acid nephropathy (FAN) models were used to establish the role of C5aR1 in kidney tubules during AKI in germline C5ar1, myeloid cell-specific, and kidney tubule-specific C5ar1 knockout mice.

Activation of platelets and the complement system in mice with -induced pulmonary hypertension.

Schistosomiasis-induced pulmonary hypertension (PH) presents a significant global health burden, yet the underlying mechanisms remain poorly understood. Here, we investigate the involvement of platelets and the complement system in the initiation events leading to -induced PH. We demonstrate that exposure leads to thrombocytopenia, platelet accumulation in the lung, and platelet activation.