Evaluation of AI-based auto-contouring tools in radiotherapy: A single-institution study.

Background: Accurate delineation of organs at risk (OARs) is crucial yet time-consuming in the radiotherapy treatment planning workflow. Modern artificial intelligence (AI) technologies had made automation of OAR contouring feasible. This report details a single institution's experience in evaluating two commercial auto-contouring software tools and making well-informed decisions about their clinical adoption.

Association of Fontan Pathophysiology With Plasma Bile Acids.

Background: Patients with Fontan circulation are frail and experience multisystem dysfunction including impaired exercise capacity, low resting and exercise-augmented cardiac output, and progressive liver fibrosis. However, common underlying biochemical abnormalities or disease-specific biomarkers have not been well-described.

Objectives: We wish to investigate Fontan and their matched healthy subjects using a nontargeted, followed by targeted metabolomic analysis.

Sulfides as environmental stressors in Paracas Bay, Peru.

Paracas Bay, located in the Humboldt Current system, is a highly variable coastal environment where hypoxia (dissolved oxygen concentrations <2 mg L) has been reported as a persistent feature of bottom conditions. In addition to hypoxia, milky water events have been reported in the bay, most likely associated with the presence of sulfides (i.e.

Mapping TcdB interactions with host cell-surface and intracellular factors using proximity-dependent biotinylation labeling.

Many bacterial toxins exert their cytotoxic effects by enzymatically inactivating one or more cytosolic targets in host cells. To reach their intracellular targets, these toxins possess functional domains or subdomains that interact with and exploit various host factors and biological processes. Despite great progress in identifying many of the key host factors involved in the uptake of toxins, significant knowledge gaps remain as to how partially characterized and newly discovered microbial toxins exploit host factors or processes to intoxicate target cells.