Publications by authors named "J W Steele"
Article Synopsis
- Agitation in people with cognitive decline is a challenging behavior that affects caregivers, often leading to earlier long-term care placement and faster disease progression.
- The MODERATE study aims to characterize agitation using technology and identify potential triggers by monitoring participants with mild cognitive impairment or dementia in their home environment.
- Preliminary analysis of data from 8 participants suggests that longer wake durations after sleep onset may be linked to increased agitation levels, highlighting the importance of sleep behaviors in managing agitation.
Glioblastoma multiforme (GBM), the most aggressive primary brain tumour, exhibits low survival rates due to its rapid growth, infiltrates surrounding brain tissue, and is highly resistant to treatment. One major challenge is oedema infiltration, a fluid build-up that provides a path for cancer cells to invade other areas. MRI resolution is insufficient to detect these infiltrating cells, leading to relapses despite chemotherapy and radiotherapy.
View Article and Find Full Text PDFLong-term outcomes of pediatric temporal bone fractures with hearing loss: Results of a multinational database analysis.
Int J Pediatr Otorhinolaryngol
December 2024
Introduction: Pediatric temporal bone fractures (TBFs) can result in adverse outcomes including meningitis, significant sensorineural hearing loss requiring cochlear implantation (CI), facial nerve weakness, cerebrospinal fluid (CSF) leak, and labyrinthitis. The objective of this study is to determine the risks of these outcomes for TBFs with hearing loss.
Methods: Using the multinational TriNetX database, a retrospective cohort study was performed of patients less than 18 years old with diagnostic codes for other fracture of base of skull and hearing loss to serve as an approximation of TBF.
The gut microbiota is a crucial link between diet and cardiovascular disease (CVD). Using fecal metaproteomics, a method that concurrently captures human gut and microbiome proteins, we determined the crosstalk between gut microbiome, diet, gut health, and CVD. Traditional CVD risk factors (age, BMI, sex, blood pressure) explained < 10% of the proteome variance.
View Article and Find Full Text PDFRO and ChRCC are kidney tumours with overlapping characteristics, making differentiation between them challenging. The objective of this research is to create a radiogenomics map by correlating radiomic features to molecular phenotypes in ChRCC and RO, using resection as the gold standard. Fourteen patients (6 RO and 8 ChRCC) were included in the prospective study.
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