Publications by authors named "J W Sleasman"
Regulatory T cells (Tregs) actively engage in immune suppression to prevent autoimmune diseases but also inhibit anti-tumor immunity. Although Tregs express a TCR repertoire with relatively high affinities to self, they are normally quite stable and their inflammatory programs are intrinsically suppressed. We report here that diacylglycerol (DAG) kinases (DGK) ( and ( are crucial for homeostasis, suppression of proinflammatory programs, and stability of Tregs and for enforcing their dependence on CD28 costimulatory signal.
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- Pathogenic variants in a specific transcription factor are linked to syndromes like EEC and AEC, and this case report presents an infant with severe T cell lymphopenia, detected during newborn screening.
- Flow cytometry revealed low levels of CD4+ and almost no CD8+ T cells, while the B and NK cell levels were normal; further genetic analysis identified a particular variant in the transcription factor.
- Using an artificial thymic organoid system, researchers found that T cell differentiation occurred, implying a thymic defect, leading to the patient receiving an allogenic cultured thymus tissue implant, which showed promising signs of T cell development after 9 months.
Article Synopsis
- HIV-exposed uninfected (HEU) infants show higher levels of pro-inflammatory biomarkers that continue after birth, potentially influenced by maternal immunity in pregnant women with HIV (PWH).
- The study analyzed plasma samples from 46 HEU infants and their mothers, comparing results with pregnant women without HIV (PWOH) and their HIV unexposed uninfected (HUU) newborns.
- Results indicated that both PWH and HEU infants have elevated immune biomarkers, but many of these levels normalized in HEU infants by 6 months, suggesting the short-term effects of maternal inflammation on their immune development.
A 20-year-old male patient with a history of celiac disease came to medical attention after developing profound fatigue and pancytopenia. Evaluation demonstrated pan-hypogammaglobulinemia. There was no history of significant clinical infections.
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