Publications by authors named "J W Sievers"
Revisiting the antiangiogenic mechanisms of fluorinated thalidomide derivatives.
Bioorg Med Chem Lett
September 2024
Article Synopsis
- - The introduction of fluorine into drugs, specifically tetrafluorination of phthalimide in immunomodulatory drugs (IMiDs), enhances their ability to inhibit angiogenesis, a key process in cancer growth.
- - Research examined a series of thalidomide analogs, revealing that neither fluorinated nor non-fluorinated versions effectively induced the degradation of certain neomorphic substrates linked to their activity, indicating that fluorine does not contribute to this degrading mechanism.
- - A study of non-traditional IMiDs showed no effective angiogenesis inhibitors through endothelial cell tube formation tests, highlighting the limited scope of IMiD's antiangiogenic potential.
Chronic progressive lymphedema (CPL) is a prevalent and progressive disease in Rhenish German draught horses. The objective of our follow-up study was to evaluate the heritability of this disease in Rhenish German draught horses using pedigree-based and genomic relationship matrices. We employed linear and threshold animal models.
View Article and Find Full Text PDFIn GEMINI-1/-2, dolutegravir + lamivudine was non-inferior to dolutegravir + tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) in achieving viral suppression (viral load [VL] < 50 copies/mL) in treatment-naive adults. Abbott's RealTime HIV-1 assay provides quantitative VL (40-10,000,000 copies/mL) and qualitative target detected or target not detected (TND) for VL < 40 copies/mL. This post hoc analysis assessed very-low-level viremia and "blips" through Week 144.
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