Publications by authors named "J W Ronnie Teo"
Background: Inhibitors of the renin-angiotensin-aldosterone system (RAAS), such as ACE inhibitors (ACEi), angiotensin-II receptor blockers and mineralocorticoid receptor antagonists, reduce morbidity and mortality in hypertension, congestive heart failure and chronic kidney disease. However, their use can lead to hyperkalaemia. We examined the proportions of RAAS inhibitor (RAASi) reduction or withdrawal, across GFR strata, following hospitalisation and the effect on patient mortality.
View Article and Find Full Text PDFSphingosine Kinase 1 - A Therapeutic Opportunity for Alleviating Liver Fibrosis?
Cell Mol Gastroenterol Hepatol
December 2024
Article Synopsis
- Tumor-associated neutrophils (TANs) vary in function depending on the type of cancer, with their role being more significant in metabolic dysfunction-related liver cancer than in viral-related liver cancer.* -
- In metabolic dysfunction-associated hepatocellular carcinoma (MASH-related HCC), specific TANs (SiglecFhi) promote tumor growth and immune evasion by enhancing stemness and inhibiting the immune response.* -
- Targeting SiglecFhi TANs can improve the effectiveness of immunotherapy, as their removal increases cancer cell recognition and correlates with poor patient outcomes due to resistance to treatment.*