Publications by authors named "J W ROBSON"
Single-cell transcriptomics, which utilises barcodes and unique molecular identifiers (UMIs) for polyA+ mRNA capture, is compromised by oligonucleotide synthesis errors. To address this, we modified the oligonucleotide capture design and integrated an interposed anchor between the barcode and the UMI. This design significantly reduces the need to discard reads due to synthesis inaccuracies.
View Article and Find Full Text PDFPublic Health England outlines a national ambition of anticoagulating 90% of eligible patients with atrial fibrillation (AF) by 2029. In 2019/2020, two out of three boroughs reviewed in this study were in the bottom 10% of boroughs compared with others within England. Stroke National Audit data for these three boroughs from 2019 to 2020 identified that in patients with known AF admitted to hospital with strokes, 37% were not anticoagulated.
View Article and Find Full Text PDFIntroduction: There is no consensus amongst patients and healthcare professionals about how to measure important adverse effects of glucocorticoids (GCs) that includes the patient's perspective. The OMERACT GC Impact working group sought to identify the domains of greatest importance to both patients and healthcare professionals for use in a proposed core outcome set.
Methods: Patients and healthcare professionals participated in a Delphi consensus exercise to rate the importance of previously identified candidate domains.
Background: Cardiovascular disease has declined but remains a major disease burden across developed countries.
Objective: To assess the effectiveness and cost-effectiveness of statin therapy across United Kingdom population categories.
Design: The cardiovascular disease microsimulation model, developed using Cholesterol Treatment Trialists' Collaboration data and the United Kingdom Biobank cohort, projected cardiovascular events, mortality, quality of life and healthcare costs using participant characteristics.
Article Synopsis
- A mixed methods evaluation was conducted to assess a digital call-and-recall tool aimed at improving the timely receipt and equity of MMR and DTaP/IPV vaccinations in North East London, focusing on children eligible from January 2019 to January 2024.
- The findings showed a 5.3% increase in timely first MMR vaccinations (from 77.7% to 81.8%), while DTaP/IPV saw a smaller increase of 0.9%. However, no significant change in inequality was observed.
- Users found the tool helpful for recall but noted challenges such as staff dynamics and unrealistic national targets that hindered its consistent application; further support is needed to maintain improvements.