Exploring the potential benefits of growth hormone co-treatment on embryo quality in IVF: a randomized controlled open-label trial.

Research Question: While growth hormone (GH) is hypothesized to potentially enhance embryo quality, results of current basic and clinical researches remain inconclusive. This study assesses the effect of GH supplementation on embryo quality and explores the relationship between baseline insulin-like growth factor-1 (IGF-1) levels and the efficacy of GH supplementation among Chinese patients undergoing in vitro fertilization (IVF).

Design: A randomized controlled Open-label trial was performed with 128 women experiencing poor embryonic development in IVF.

Oral ADC189 for Adults and Adolescents with Uncomplicated Influenza.

Objectives: ADC189 is a novel anti-influenza virus inhibitor. In this study, we aimed to evaluated the safety and efficacy of ADC189 in outpatients with uncomplicated influenza infection.

Methods: In the phase 2 trial, we assigned patients in a 2:2:1 ratio to receive either single dose 15-mg or 45-mg of ADC189 or placebo.

Establishment of an efficacy-oriented quality grading framework for herbal medicines: Phyllanthus emblica as an example.

Ethnopharmacological Relevance: Quality control is a powerful method for ensuring the effectiveness and safety of herbal medicines. Phyllanthus emblica L. fruit (PE) has been extensively used in both Ayurvedic and traditional Chinese medicine.

Acoustic nonlinearity parameters in hyperelastic solids with quadratic nonlinearity.

In general, the nonlinear behavior of an elastic wave in isotropic hyperelastic solids with quadratic nonlinearity depends on five independent elastic constants, namely, the three third-order elastic constants and two second-order elastic constants. In this article, we show that such nonlinear behavior can be described fully by only three independent non-dimensional parameters if the wave motion is two-dimensional. Furthermore, if the motion is a plane wave, only two independent non-dimensional parameters are needed to fully describe the nonlinear behavior of the wave.

SIRT5 safeguards against primate skeletal muscle ageing via desuccinylation of TBK1.

Ageing-induced skeletal muscle deterioration contributes to sarcopenia and frailty, adversely impacting the quality of life in the elderly. However, the molecular mechanisms behind primate skeletal muscle ageing remain largely unexplored. Here, we show that SIRT5 expression is reduced in aged primate skeletal muscles from both genders.