Publications by authors named "J W McGuiness"
Article Synopsis
- Cancer immunotherapy faces challenges due to poor antigen recognition and an unfriendly tumor microenvironment (TME).
- Researchers developed "onion-like" multi-lamellar RNA lipid particle aggregates (LPAs) that enhance the delivery and effectiveness of tumor mRNA antigens by activating specific immune responses in the body.
- In studies with dogs and humans, RNA-LPAs showed promising results, improving survival rates and triggering strong immune reactions against tumors, suggesting they could be a breakthrough method for cancer treatment.
Messenger RNA (mRNA) has emerged as a remarkable tool for COVID-19 prevention but its use for induction of therapeutic cancer immunotherapy remains limited by poor antigenicity and a regulatory tumor microenvironment (TME). Herein, we develop a facile approach for substantially enhancing immunogenicity of tumor-derived mRNA in lipid-particle (LP) delivery systems. By using mRNA as a molecular bridge with ultrapure liposomes and foregoing helper lipids, we promote the formation of 'onion-like' multi-lamellar RNA-LP aggregates (LPA).
View Article and Find Full Text PDFIntroduction: Brain tumors remain especially challenging to treat due to the presence of the blood-brain barrier. The unique biophysical properties of nanomaterials enable access to the tumor environment with minimally invasive injection methods such as intranasal and systemic delivery.
Methods: In this review, we will discuss approaches taken in NP delivery to brain tumors in preclinical neuro-oncology studies and ongoing clinical studies.
We tested whether indomethacin or rosiglitazone treatment could rejuvenate spatial ability and hippocampal neurogenesis in aging rats. Young (4 mo; = 30), middle-aged (12 mo; = 31), and aged (18 mo; = 31) male Fischer 344 rats were trained and then tested in a rapid acquisition water maze task and then fed vehicle (500 μl strawberry milk), indomethacin (2.0 mg/ml), or rosiglitazone (8.
View Article and Find Full Text PDFRationale, Aims And Objectives: As patients move across transition points, effective medication management is critical for patient safety. The aims of this study were to examine how health professionals, patients and family members communicate about managing medications as patients moved across transition points of care and to identify possible sources of communication failure.
Method: A descriptive approach was used involving observations and interviews.