Background: Pseudotumor cerebri (PTC) syndrome is a disorder of increased intracranial pressure, most commonly affecting overweight women of childbearing age. Malignant PTC (MPTC) is a rare presentation that involves rapidly worsening vision, often necessitating surgical intervention to prevent permanent vision loss. The goal of this study was to determine whether radiographic findings of PTC are predictive of MPTC and the final visual outcome.
View Article and Find Full Text PDFVariational flooding is an enhanced sampling method for obtaining kinetic rates from molecular dynamics simulations. This method is inspired by the idea of conformational flooding that employs a boost potential acting along a chosen reaction coordinate to accelerate rare events. In this work, we show how the empirical distribution of crossing times from variational flooding simulations can be modeled with analytical Kramers' time-dependent rate (KTR) theory.
View Article and Find Full Text PDFBackground: Almost all acquired severe aplastic anaemia is immune mediated and characterised by hypocellular bone marrow and ≥2 affected haematopoietic lineages. The optimal preparartive regimen for unrelated donor transplantation remains to be established. We aimed to study long-term outcomes after unrelated donor transplantation for severe aplastic anaemia with de-escalation of cyclophosphamide (Cy) dose in steps of 50 mg/kg (150, 100, 50, 0 mg/kg) in combination with total body irradiation (TBI) 2 Gy, anti-thymocyte globulin (ATG) and fludarabine.
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