Effects of a 12-week lower limb resistance training with breathing regulation in patients with diabetes-related foot ulcers: A randomized controlled trial.

Patients with diabetes-related foot ulcers may require hospitalization and face an increased risk of amputation, which can significantly impact their quality of life. One potential solution is exercise, which can regulate blood glucose levels, improve wound healing, and enhance overall well-being. This randomized controlled trial aimed to evaluate the impact of a lower limb resistance training program combined with breathing-regulation techniques on glycemic control, wound healing, and quality of life in patients with diabetes-related foot ulcers.

Dendritic fibrous nanosilica supported Zn-based sorbents towards enhanced hot-coal-gas desulfurization: Structural design and metal modification.

Designing suitable carriers of sorbents for hot-coal-gas desulfurization is still a challenging task so far. In this study, dendritic fibrous nanosilica (DFNS) carriers with central radial pore structures were synthesized via microemulsion method, and the formation mechanism was proposed. The mean particle diameter (MPD) and mean surface wrinkle spacing (MSWS) of DFNS could be directionally controlled by regulating the emulsion phase behavior during DFNS synthesis.

Protective effect of curcumin against endoplasmic reticulum stress and lipid metabolism disorders in AFB1-intoxicated duck liver.

Aflatoxin B1 (AFB1) is a stable and highly toxic toxin that causes multi-organ toxicity with sustained ingestion, most typically in the duck liver. Previous research has shown that AFB1 can bring about endoplasmic reticulum stress (ERS) in animals, and ERS is strongly associated with lipid metabolism. However, the relationship between AFB1-induced duck liver toxicity and ERS and lipid metabolism is currently unclear.

Notch1 signaling regulates Sox9 and VEGFA expression and governs BMP2-induced endochondral ossification of mesenchymal stem cells.

Although bone morphogenetic protein 2 (BMP2) can induce chondrogenic differentiation of mesenchymal stem cells (MSCs), its induction of endochondral ossification limits the application of BMP2-based cartilage regeneration. Here, we clarified the mechanisms of BMP2-induced endochondral ossification of MSCs. and chondrogenic, osteogenic, and angiogenic differentiation models of MSCs were constructed.

Engineering Protein-Polyelectrolyte Interactions for Cellular Applications.

Protein-polyelectrolyte interactions are fundamental interactions in biology that occur at every length scale, from protein-DNA complexes to phase-separated organelles. They drive processes ranging from gene transcription and DNA synthesis to viral assembly. Protein engineering is a powerful way to modulate these interactions, both to probe endogenous function and to engineer novel interactions between species.