Microbial communities in biosolids-amended soils: A critical review of high-throughput sequencing approaches.

Sustainable reuse of treated wastewater sludge or biosolids in agricultural production requires comprehensive understanding of their risks and benefits. Microbes are central mediators of many biosolids-associated risks and benefits, however understanding of their responses to biosolids remains minimal. Application of biosolids to soils amounts to a coalescence of two distinct microbial communities adapted to vastly different matrices.

Development and External Validation of the Hidradenitis Suppurativa Cutaneous Abscess Prediction Score-2 (HSCAPS-2): A Clinical Decision Support Tool for Diagnosis of Hidradenitis Suppurativa over Cutaneous Abscess.

Introduction: Patients with hidradenitis suppurativa (HS) experience a 10-year diagnosis delay, on average. Accordingly, time to diagnosis represents one of the greatest unmet needs in HS, which to date has not been adequately addressed. A general lack of awareness about HS in the medical community and a notable heterogeneity in clinical presentation, which is most often confused with cutaneous abscess (CA), forms the basis of poor disease recognition and diagnosis delay.

Examining the Impact of a Brief Compassion Focused Intervention on Everyday Experiences of Compassion in Autistic Adults Through Psychophysiology and Experience Sampling.

Autistic adults experience greater rates of anxiety and depression compared to the general population. Compassion-focused therapy interventions, aimed at promoting self-compassion capabilities, have shown efficacy in improving mental health outcomes in autistic and non-autistic samples suffering from self-criticism that contribute to difficulties in emotion regulation. We explored the experiences of autistic adults during a brief one-week online self-compassion exercise to evaluate it's feasibility and acceptability through self-report, experience sampling, and parasympathetic activity measured via HRV.

Development of CGS-15943 Adjunctives for the Disruption of Plasmid Maintenance in Multidrug Resistant .

Carbapenemase producing (CPEs) represent a group of multidrug resistant pathogens for which few, if any, therapeutics options remain available. CPEs generally harbor plasmids that encode resistance to last resort carbapenems and many other antibiotics. We previously performed a high throughput screen to identify compounds that can disrupt the maintenance and replication of resistance conferring plasmids through use of a synthetic screening plasmid introduced into K-12 cells.

North American clinical practice guidelines for the medical management of hidradenitis suppurativa in special patient populations.

Background: Hidradenitis suppurativa (HS) affects different patient populations that require unique considerations in their management. However, no HS guidelines for these populations exist.

Objective: To provide evidence-based consensus recommendations for patients with HS in 7 special patient populations: (i) pregnancy, (ii) breastfeeding, (iii) pediatrics, (iv) malignancy, (v) tuberculosis infection, (vi) hepatitis B or C infection, and (vii) HIV disease.