Publications by authors named "J W Jang"

Diffuse gastric adenocarcinoma (DGAC) is an aggressive malignancy with limited therapeutic options, poor prognosis, and poorly understood biology. CRACD, an actin polymerization regulator, is often inactivated in gastric cancer, including DGAC. We found that genetic engineering of murine gastric organoids with ablation combined with mutation and loss induced aberrant cell plasticity, hyperproliferation, and hypermucinosis, the features that recapitulate DGAC transcriptional signatures.

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Background: Congenital anomalies (CAs) encompass a wide spectrum of structural and functional abnormalities during fetal development, commonly presenting at birth. Identifying the cause of CA is essential for accurate diagnosis and treatment. Using a target-gene approach, genetic variants could be found in certain CA patients.

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Background: Malnutrition exacerbates the prognosis of various diseases; however, its specific impact on severe coronavirus disease (COVID-19) outcomes remains underexplored.

Methods: This multicenter study in Korea assessed the nutritional status of 1,088 adults with severe COVID-19 using the Geriatric Nutritional Risk Index (GNRI) based on serum albumin levels and body weight. The patients were divided into the GNRI>98 (no-risk) and GNRI≤98 (risk) groups.

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Monolayer transition metal dichalcogenides are promising materials that not only are atomically thin but also have direct bandgaps, making them highly regarded in optics and optoelectronics. However, their photoluminescence exhibits almost random polarization at room temperature. The emission is also omnidirectional and weak due to the low quantum yield.

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The self-replication of misfolded prion protein (PrP) aggregates is the major pathological event of different prion diseases, affecting mammal brains by cross-species transmission. Here, the structural modulation of PrP aggregates are reported by activated carbon materials upon near-infrared (NIR) light irradiation. Activated carbon cobalt (ACC) nanosheets are synthesized using glycerol and metal salts to utilize the charge carriers released under NIR light exposure.

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