Reinterpretation of Conflicting ClinVar Missense Variants Using VarSome and CanVIG-UK Gene-Specific Guidance.

Background: The accurate interpretation of the /2 variant is critical for diagnosing and treating hereditary breast and ovarian cancers. ClinVar is a widely used public database for genetic variants. Conflicting classifications of pathogenicity can occur when different submitters categorize the same genetic variant inconsistently as pathogenic (PV), likely pathogenic (LPV), likely benign (LBV), benign (BV), or a variant of uncertain significance (VUS).

Crystallization control of Cu(I)-halide thermal evaporation for improving resistive switching memory performance.

CsCuI is considered a promising material for lead-free resistive switching (RS) memory devices due to its low operating voltage, high on/off ratio, and excellent thermal and environmental stability. However, conventional lead-free halide-based RS memory devices typically require solvent-based thin-film formation processes that involve toxic organic and acidic solvents, and the effects of process conditions on device performance are often not fully understood. This study investigates the effect of crystallinity on CsCuI-based RS memory devices fabricated thermal evaporation.

Association between calcium channel blocker use and the risk of interstitial lung disease and idiopathic pulmonary fibrosis: A longitudinal cohort study.

Introduction: Ca2+ signaling in fibroblasts would be one of the important mediators of lung fibrosis. This study investigated the relationship between calcium channel blocker usage and the risk of developing interstitial lung disease and idiopathic pulmonary fibrosis.

Material And Methods: This cohort study used data from the Korean National Health Screening Cohort spanned from January 1, 2004, to December 31, 2015.

Seasonal effect of PM exposure in patients with COPD: a multicentre panel study.

: Exposure to particulate matter <2.5 μm (PM) is linked to chronic obstructive pulmonary disease (COPD), but most studies lack individual PM measurements. Seasonal variation and their impact on clinical outcomes remain understudied.