Genetically engineered biomimetic ATP-responsive nanozyme for the treatment of cardiac fibrosis.

Background: Cardiac fibrosis plays a critical role in the progression of various forms of heart disease, significantly increasing the risk of sudden cardiac death. However, currently, there are no therapeutic strategies available to prevent the onset of cardiac fibrosis.

Methods And Results: Here, biomimetic ATP-responsive nanozymes based on genetically engineered cell membranes are adapted to specifically recognize activated cardiac fibroblasts (CFs) for the treatment of cardiac fibrosis.

Subgroups of cognitive impairments in schizophrenia characterized by executive function and their morphological features: a latent profile analysis study.

Background: The heterogeneity of cognitive impairments in schizophrenia has been widely observed. However, reliable cognitive boundaries to differentiate the subgroups remain elusive. The key challenge for cognitive subtyping is applying an integrated and standardized cognitive assessment and understanding the subgroup-specific neurobiological mechanisms.

Chitosan/Alginate-Based Hydrogel Loaded With VE-Cadherin/FGF as Scaffolds for Wound Repair in Different Degrees of Skin Burns.

Burns are complex traumatic injuries that lead to severe physical and psychological problems due to the prolonged healing period and resulting physical scars. Owing to their versatility, hydrogels can be loaded with various functional factors, making them promising wound dressings. However, many hydrogel dressings cannot support cell survival for a long time, thereby delaying the process of tissue repair.

Telomere-to-telomere sheep genome assembly identifies variants associated with wool fineness.

Ongoing efforts to improve sheep reference genome assemblies still leave many gaps and incomplete regions, resulting in a few common failures and errors in genomic studies. Here, we report a 2.85-Gb gap-free telomere-to-telomere genome of a ram (T2T-sheep1.

Peony diagram modeling for improving the easy disassembly design of mobile electronic products.

Designing mobile electronic products for easy disassembly is crucial for promoting resource recycling. However, many current approaches overlook the need to consider the disassembly of parts from the perspective of the overall product structure and practical recycling requirements, leading to potentially suboptimal or unnecessary optimization strategies. This study introduces a novel visual disassembly information model called the "Peony Diagram.