Publications by authors named "J W Helge"
Article Synopsis
- Breast cancer patients experience a heightened risk of cardiometabolic diseases, exacerbated by adjuvant therapies that alter inflammatory and metabolic health markers.
- A study measured inflammatory cytokines and metabolic health parameters in 51 postmenopausal early breast cancer patients over two years, revealing significant increases in cytokines immediately after chemotherapy.
- Although cytokine levels returned to near baseline within six months, patients continued to show worsened lipid profiles and insulin resistance for up to a year post-treatment.
Article Synopsis
- This study investigated how TNF-α inhibitor adalimumab affects inflammation and mitochondrial function in adipose tissue in patients with hidradenitis suppurativa (HS) after 12 weeks of treatment.
- Findings showed that while patients had a greater presence of anti-inflammatory macrophages, treatment did not significantly change overall adipose tissue inflammation or mitochondrial respiration.
- Additionally, patients experienced improved quality of life scores, even though clinical symptoms remained unchanged.
It is not clear if fat oxidation is attenuated at higher exercise intensities, when exercising with a small muscle mass, and therefore, we studied leg fat oxidation during graded one-leg exercise. Ten males (age: 27 ± 2 years, body mass: 82 ± 3 kg, BMI: 24 ± 1 kg m, V̇O: 49 ± 2 mL min kg) performed one-leg exercise at 25% of maximal workload (W) for 30 min, followed by 120-min exercise at 55% W with the contralateral leg, and finally 30-min exercise at 85% W with the first leg. Blood was sampled from an artery and both femoral veins, and blood flow was determined using Doppler ultrasound.
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- The study investigates how resting heart rate variability (HRV) relates to metabolic flexibility, specifically fat and carbohydrate oxidation rates, in active women over 60 years old.
- Twenty-four women participated in the study, which involved HRV measurements and a cycling test to determine the maximum fat oxidation (MFO) and carbohydrate oxidation (MCO) rates.
- Findings indicate a moderate significant relationship between certain HRV metrics and fat oxidation rates, suggesting better autonomic function is linked to improved metabolic flexibility in aging women.