Publications by authors named "J W Haycock"
Controlling biomolecular-cell interactions is crucial for the design of scaffolds for tissue engineering (TE). Regenerated silk fibroin (RSF) has been extensively used as TE scaffolds, however, RSF showed poor attachment of neuronal cells, such as rat pheochromocytoma (PC12) cells. In this work, amphiphilic peptides containing a hydrophobic isoleucine tail (I) and laminin or fibronectin derived peptides (IKVAV, PDSGR, YIGSR, RGDS and PHSRN) were designed for promoting scaffold-cell interaction.
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- The immune system of Asian elephants is not as well-researched as that of other animals, making understanding their response to diseases like EEHV-HD vital.
- EEHV-HD, caused by herpesviruses, poses a serious threat to captive Asian elephants, with a strong innate immune response needed to prevent fatal outcomes.
- The study tested two veterinary immunostimulants, finding they effectively boosted the innate anti-viral immune responses in elephant blood cells, hinting at their potential use in managing EEHV infections.
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- This study examined how men and women differ in their responses to cognitive behavioral therapy for insomnia (CBT-I), focusing on a large group of clinical participants.
- Researchers reviewed patient charts, comparing symptoms and sleep patterns before and after treatment using several questionnaires, while also considering factors like age and body mass index (BMI).
- Results showed that while females initially had worse insomnia symptoms than males, both sexes experienced significant improvements after CBT-I, though some differences in depressive symptoms were noted, which disappeared when adjusting for other variables.
Polyhydroxyalkanoates are natural, biodegradable, thermoplastic and sustainable polymers with a huge potential in fabrication of bioresorbable implantable devices for tissue engineering. We describe a comparative evaluation of three medium chain length polyhydroxyalkanoates (mcl-PHAs), namely poly(3-hydroxyoctanoate), poly(3-hydroxyoctanoate-co-3-hydoxydecanoate) and poly(3-hydroxyoctanoate-co-3-hydroxydecanoate-co-3-hydroxydodecanoate), one short chain length polyhydroxyalkanoate, poly(3-hydroxybutyrate), P(3HB) and synthetic aliphatic polyesters (polycaprolactone and polylactide) with a specific focus on nerve regeneration, due to mechanical properties of mcl-PHAs closely matching nerve tissues. biological studies with NG108-15 neuronal cell and primary Schwann cells did not show a cytotoxic effect of the materials on both cell types.
View Article and Find Full Text PDFSilane modification is a simple and cost-effective tool to modify existing biomaterials for tissue engineering applications. Aminosilane layer deposition has previously been shown to control NG108-15 neuronal cell and primary Schwann cell adhesion and differentiation by controlling deposition of ─NH groups at the submicron scale across the entirety of a surface by varying silane chain length. This is the first study toreport depositing 11-aminoundecyltriethoxysilane (CL11) onto aligned Polycaprolactone (PCL) scaffolds for peripheral nerve regeneration.
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