Publications by authors named "J W Goldfarb"
Objective: This systematic review and meta-analysis compares the efficacy and complication rate of absorbable versus non-absorbable 3D-printed, patient-customized, maxillofacial implants in facial trauma patients.
Data Sources: A comprehensive search of four databases (PubMed, Scopus, Web of Science, and Cochrane) was conducted.
Methods: A systematic review and single-proportion meta-analysis was conducted employing PRISMA guidelines.
Functional outcomes after ankle fracture-dislocation: a systematic review.
Arch Orthop Trauma Surg
January 2025
Introduction: Ankle fractures represent a significant portion of orthopedic injuries, with fracture dislocations tending to have worse outcomes. Logsplitter fractures represent a subset of fracture dislocations in which the talus is axially wedged in the tibiofibular joint. We aim to comprehensively investigate and report on the complications and functional outcomes associated with ankle fracture-dislocations.
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- - Chronic low back pain (CLBP) significantly affects individuals' physical and emotional health, leading to high healthcare costs and reduced productivity, yet there is a gap in adopting recommended nonpharmacologic treatments like yoga in practice.
- - The study aimed to assess the effectiveness of virtual yoga classes over a wait-list control in reducing CLBP intensity, improving back-related function, enhancing sleep quality, and decreasing pain medication use in adults aged 18 to 64.
- - Conducted as a 24-week randomized clinical trial with participants receiving 12 weeks of live streamed hatha yoga classes, the main outcomes focused on measuring pain intensity and disability after 12 weeks, with follow-up assessments at 24 weeks to gauge broader impacts.
Article Synopsis
- Hypoglossal nerve stimulation (HGNS) is being studied as a treatment for patients with obstructive sleep apnea (OSA) who cannot tolerate CPAP, using the modified sleep apnea severity index (mSASI) to assess its efficacy and adherence.
- A retrospective study of 264 patients found that, while there were no significant differences in device usage hours based on mSASI levels, higher mSASI scores correlated with greater daytime sleepiness post-HGNS.
- Overall, preoperative mSASI did not significantly affect HGNS adherence, suggesting a need for further research on its utility in this patient group.
Article Synopsis
- A study investigates how drug-induced gene expression profiles can reveal mechanisms of cardiotoxicity in FDA-approved tyrosine kinase inhibitors (TKIs) using human stem cell-derived heart cells.
- The research employs singular value decomposition to detect drug-specific patterns in cells from various healthy individuals, highlighting affected cellular pathways like energy metabolism and contractile functions.
- The findings suggest that integrating mRNA expression data with genomic and pathway information can create comprehensive signatures for cardiotoxicity, aiding in drug development and personalized treatment strategies.