Publications by authors named "J W Forstrom"
Article Synopsis
- Dystonia is the third most common movement disorder and can be caused by injury or genetic mutations, with unclear underlying mechanisms.
- Dysregulation of eIF2α phosphorylation is observed in dystonia, and experiments using a Drosophila model revealed that altering eIF2α-P levels leads to dystonia-like movements and changes in synaptic structure.
- Long-term treatment with ISRIB to restore eIF2α-P levels improved longevity but did not enhance motor function, indicating that disrupted signaling may impact neuronal connectivity and motor circuits in dystonia.
Article Synopsis
- * New cases revealed individuals with microdeletions in AGAP1 exhibited various neurodevelopmental issues, including intellectual disability and autism, along with other physical and developmental challenges.
- * Research in fruit flies suggested that AGAP1 disruption leads to problems in cellular transport processes, increased susceptibility to stress, and highlights the interaction between genetic vulnerabilities and environmental factors in neurodevelopmental disorders.
Unlabelled: is an Arf1 GAP that regulates endolysosomal trafficking. Damaging variants have been linked to cerebral palsy and autism. We report 3 new individuals with microdeletion variants in .
View Article and Find Full Text PDFAlthough immobilized metal affinity chromatography (IMAC) offers high capacity and protein selectivity it is not typically used commercially for the capture of native proteins from mammalian cell culture harvest. This is due mainly to the potential for low target recovery due to the presence of strong metal ion chelating species in the harvest that compete for the metal immobilized on the resin. To address this issue a buffer exchange step, such as tangential flow filtration (TFF), is added after harvest clarification and prior to IMAC to remove the interfering harvest components.
View Article and Find Full Text PDFAims: To investigate a recently developed pain-intensity matching device (Painmatcher) in terms of reproducibility, pain intensity, and unpleasantness experienced by healthy individuals upon pain threshold assessment, as well as differences in pain threshold between genders and between healthy individuals and patients with acute oral pain, and the relation between pain-intensity assessments by the Painmatcher and a visual analog scale (VAS) in the patients.
Methods: Forty healthy individuals and 28 patients with acute oral pain participated. The Painmatcher produces an eventually noxious stimulus by increasing electrical impulses between 2 fingers.