Publications by authors named "J W Fisher"

Mammalian genomes contain millions of regulatory elements that control the complex patterns of gene expression. Previously, The ENCODE consortium mapped biochemical signals across many cell types and tissues and integrated these data to develop a Registry of 0.9 million human and 300 thousand mouse candidate cis-Regulatory Elements (cCREs) annotated with potential functions .

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Non-invasive, low intensity focused ultrasound is an emerging neuromodulation technique that offers the potential for precision, personalized therapy. An increasing body of research has identified mechanosensitive ion channels that can be modulated by FUS and support acute electrical activity in neurons. However, neuromodulatory effects that persist from hours to days have also been reported.

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Article Synopsis
  • There’s a growing issue of burnout among health professionals, prompting academic medical centers to prioritize well-being initiatives.
  • The Wellness Initiative Supporting Health (WISH) program was launched to fund wellness projects, with 52% of proposals receiving grants between 2018 and 2022.
  • Participating in these projects led to improved wellness among participants and strong support for continuing the program, demonstrating the viability of local wellness initiatives in academic settings.
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  • Wolverines have faced significant range reduction globally, with complete extirpation from eastern Canada and some western prairie regions.
  • In Alberta, where they are designated for conservation, researchers aimed to estimate wolverine abundance using existing density data and habitat relationships.
  • Results indicated approximately 955 wolverines in the province, with only 544 classified as adults, suggesting a need for a reassessment of their conservation status and related protective measures.
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The proportion of older individuals needing liver transplantation is growing, resulting in an increasingly frail patient population. Frailty constitutes a constellation of cognitive and physical symptoms associated with aging and increases the risk of morbidity and mortality. Senescence is a programmed cell fate in response to stress implicated in causing frailty, age-related diseases, and aging itself.

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