Publications by authors named "J W ESCHER"
Exploring six successful nurse-led transition clinics: Experiences and outcomes.
Health Care Transit
August 2024
Background And Purpose: In the Netherlands, the 2022 Quality Standard 'Youth in transition from paediatric to adult care' underscores the importance of structured transitional care for young adults with chronic health conditions. Despite this emphasis, detailed knowledge about transition programs and their successful elements remains sparse. This study aims to bridge this gap by exploring nurse-led transition clinics that had successfully implemented core interventions such as a transition coordinator, warm handover, and individual transition plans.
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- The study focused on pediatric patients with inflammatory bowel disease (IBD) who underwent bowel resection to understand the incidence of postoperative infections and associated symptoms.
- Out of 100 patients reviewed, 42 experienced postoperative infections, predominantly superficial surgical site infections; fever was a significant indicator of infection, affecting more than half of those with fever.
- Preoperative immunomodulating therapy did not result in higher complication rates, and routine lab tests, like C-reactive protein levels, did not effectively distinguish between complications in postoperative recovery.
Gut-homing and intestinal TIGITCD38 memory T cells acquire an IL-12-induced, ex-Th17 pathogenic phenotype in a subgroup of Crohn's disease patients with a severe disease course.
Mucosal Immunol
November 2024
Article Synopsis
- CD4 memory T cell reactivation is linked to chronic inflammatory bowel disease (IBD), affecting conditions like Crohn's disease (CD) and ulcerative colitis, with unclear differences in T cell regulation among patients.
- In a study of pediatric IBD patients, a specific subgroup of therapy-naïve CD patients showed higher frequencies of a particular inflammatory T cell type (TIGITCD38T) associated with severe disease and elevated IFN-γ levels.
- The research identified IL-12 as a key driver of this inflammatory response, with increased IL-12 signaling linked to the transformation of T cells into more pathogenic forms, correlating with worsened intestinal inflammation.
Background And Aims: The effectiveness of transition programs from paediatric to adult healthcare in adolescents with inflammatory bowel disease is not clear, as prospective studies using validated outcome measures for transition are lacking. This study aimed to develop and validate a quantitative Transition Success Score, and to apply it in a multicenter setting to assess the effectiveness of transitional care.
Methods: The Top 10 outcome items related to successful transition, identified through an international Delphi study with IBD stakeholders, were integrated into a generic questionnaire, the Transition Success Score.
Telenomus remus (Hymenoptera: Scelionidae) is an efficient parasitoid of Spodoptera eggs. However, biological control programs require taxonomic, bioecological and behavioral studies of biological agents. Although the performance of T.
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