Targeting Protein Disorder for the Remediation of Antimicrobial Resistance.

The remediation of antimicrobial resistance (AMR) is a fundamental challenge for global healthcare. Intrinsically disordered proteins (IDPs) are recognized drug targets for neurodegeneration and cancer but have not been considered to date for AMR. Here, a novel link between structural disorder and AMR is identified by mapping predicted disorder profiles onto existing transcriptomic data for resistant and susceptible isolates.

Medicare Advantage Is Associated With Higher Mortality After Antibiotic Spacer Placement for Periprosthetic Joint Infection.

Background: Privatized Medicare Advantage (MA) plans are an alternative to traditional Medicare (TM). We sought to identify differences in 90-day postoperative mortality and nonfatal adverse events between TM and MA patients undergoing stage 1 antibiotic spacer placement for periprosthetic joint infection (PJI) of the hip or knee.

Methods: A nationally representative database was queried from 2015 to 2021 for adult patients undergoing stage 1 antibiotic spacer placement for PJI.

An Assessment of Back and Shoulder Postures in Single-Handed Exertions: Expanding Ergonomic Reaching Guidelines to Consider Lumbar Spine Axial Twist.

Occupational applicationsAcross a series of standing single-handed exertions performed at different lateral angles, distances, heights, and loads, lumbar axial twist exceeded an angular threshold of 9° in select exertions. Specifically, 9° of rightward axial twist was exceeded for all exertions performed laterally (90° from the body midline). Additionally, for those at the body midline, 9° of leftward axial twist was exceeded for upward exertions and exertions performed at far distances (tertiary reach envelope).

A week-long field study of seated pelvis and lumbar spine kinematics during office work.

The study objective was to quantify "natural" seated pelvis and lumbar spine kinematics over multiple days of work at individuals' workstations. Twenty participants completed five days of their usual office work while seated time was characterized from a thigh-worn activity monitor. Seated pelvic tilt and lumbar spine flexion-extension were measured from tri-axial accelerometers.

Multifaceted control of focal points along an arbitrary 3D curved trajectory.

Metalenses can integrate the functionalities of multiple optical components thanks to the unprecedented capability of optical metasurfaces in light control. With the rapid development of optical metasurfaces, metalenses continue to evolve. Polarization and color play a very important role in understanding optics and serve as valuable tools for gaining insights into our world.