Sequential emergence and quantitative dynamics of key bacterial species preceding digital dermatitis lesion onset in dairy cattle.

Digital dermatitis (DD) is a skin infection of cattle's feet with multiple bacteria suspected to be involved, yet its precise etiopathogenesis remains unclear. This longitudinal study explored the temporal changes of seven DD-associated bacteria in feet developing lesions or remaining healthy, while simultaneously investigating their persistence in potential reservoirs as sources of infection. Weekly swabs were collected from feet skin and saliva of 53 Holstein cows without DD lesions sequentially enrolled at calving in a commercial dairy herd.

Proton therapy of lung cancer patients - Treatment strategies and clinical experience from a medical physicist's perspective.

Purpose: Proton therapy of moving targets is considered a challenge. At Maastro, we started treating lung cancer patients with proton therapy in October 2019. In this work, we summarise the developed treatment strategies and gained clinical experience from a physics point of view.

Triskelion-Shaped Hexabenzocoronenes: Synthesis and Characterization of Tris-Substituted HBC Derivatives.

The synthesis of unprecedented triskelion-shaped hexa-peri-hexabenzocoronenes with C, C or D symmertry is reported. We present a new, five step synthetic access to tris-iodinated HBC derivatives carrying different solubilizing moieties (tert-butyl and mesityl), which serve as suitable building blocks for further functionalization. These molecules can undergo Sonogashira cross coupling reactions to obtain a series of seven ethynyl tris-substituted HBCs.